Purmorphamine, 5.21mg

Purmorphamine is a cell-permeable 2,6,9-trisubstituted purine compound that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC50 = 1 µM) and lineage-committed preosteoblasts MC3T3-E1. Its effect can be synergized with that of BMP-4 (bone morphogenetic protein-4). Purmorphamine induces transdifferentiation even in preadipocytes and myoblasts

CAS Number

483367-10-8

Chemical Formula

C31H32N6O2

Chemical Name

2-(3-(6-methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine

Molecular Weight

520.6

QC Specifications

MASS Spec

Mouse ESC culture for toxicity

Shipping Information

on blue ice

Storage

4°C protected from light

Stability

Stable for up to 6 months from date of receipt when stored as directed.

Reference

1. Cooper, M.K., et al. 1998. Science. 280: 1603-1607.

2. Wu, X., et al. 2004. Chem. Biol. 11: 1229-1238.

3. Beachy, P.A., et al. 2004. Nature. 432: 324-331.

4. Beloti, M.M., et al. 2005. Cell Biol. Int. 29: 537-541.

5. Sinha, S. and Chen, J.K. 2006. Nat. Chem. Biol. 2: 29-30.